Dub, Pavel A.; Tkachenko, Nikolay V.; Vyas, Vijyesh K.; Wills, Martin; Smith, Justin S.; Tretiak, Sergei published the artcile< Enantioselectivity in the Noyori-Ikariya Asymmetric Transfer Hydrogenation of Ketones>, Formula: C30H31ClN2O2RuS, the main research area is asym transfer hydrogenation ketone preparation chiral aralkyl alc cyclohexanemethanol; ruthenium arene chiral diamine catalyst asym transfer hydrogenation ketone.
Asym. transfer hydrogenation (ATH) is an important catalytic process in the fragrance and pharmaceutical industries. The Noyori-Ikariya chiral mol. ruthenium complex has been the catalyst of choice for this reaction for over 25 years. The mechanism and origin of enantioselectivity have irked chemists ever since the catalyst conception. This work addresses important shortcomings in understanding the origin of enantioselectivity with the Noyori-Ikariya catalysts, traditionally associated with the CH-π interaction. Here, we show that there are two spatial regions of the catalyst that simultaneously control the enantioselectivity for any arbitrary substrate: the region of the (tethered) η6-arene ligand and the region of the SO2 moiety. Dynamic equilibrium and interplay of attraction and repulsion via CH-π, C-H···H-C, lone pair-π, lone pair···H-C, and other noncovalent interactions in each region lead to stabilization/destabilization of the corresponding diastereomeric transition state and, as such, determine the final percent enantiomeric excess (% ee).
Organometallics published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Formula: C30H31ClN2O2RuS.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics