Miklos, Zsuzsanna; Wafa, Dina; Nadasy, Gyorgy L.; Toth, Zsuzsanna E.; Besztercei, Balazs; Dornyei, Gabriella; Laska, Zsofia; Benyo, Zoltan; Ivanics, Tamas; Hunyady, Laszlo; Szekeres, Maria published the artcile< Angiotensin II-induced cardiac effects are modulated by endocannabinoid-mediated CB1 receptor activation>, Quality Control of 96829-58-2, the main research area is Angiotensin II; CB1 cannabinoid receptor; cardiac; coronary flow; endocannabinoid; myocardial function; vasoconstriction.
Angiotensin II (Ang II) has various cardiac effects and causes vasoconstriction. Ang II activates the type-1 angiotensin receptor-Gq/11 signaling pathway resulting in the release of 2- arachidonoylglycerol (2-AG). We aimed to investigate whether cardiac Ang II effects are modulated by 2-AG-release and to identify the role of type-1 cannabinoid receptors (CB1R) in these effects. Expression of CB1R in rat cardiac tissue was confirmed by immunohistochem. To characterize short-term Ang II effects, increasing concentrations of Ang II (10-9-10-7 M); whereas to assess tachyphylaxis, repeated infusions of Ang II (10-7 M) were administered to isolated Langendorff-perfused rat hearts. Ang II infusions caused a decrease in coronary flow and ventricular inotropy, which was more pronounced during the first administration. CB agonist 2-AG and WIN55,212-2 administration to the perfusate enhanced coronary flow. The flow-reducing effect of Ang II was moderated in the presence of CB1R blocker O2050 and diacylglycerol-lipase inhibitor Orlistat. Our findings indicate that Ang II-induced cardiac effects are modulated by simultaneous CB1R-activation, most likely due to 2-AG-release during Ang II signalling. In this combined effect, the response to 2-AG via cardiac CB1R may counteract the pos. inotropic effect of Ang II, which may decrease metabolic demand and augment Ang II-induced coronary vasoconstriction.
Cells published new progress about 96829-58-2. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Quality Control of 96829-58-2.
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