Grib, Ismahene; Berredjem, Malika; Rachedi, Khadidja Otmane; Djouad, Seif-Eddine; Bouacida, Sofiane; Bahadi, Rania; Ouk, Tan-Sothea; Kadri, Mekki; Ben Hadda, Taibi; Belhani, Billel published the artcile< Novel N-sulfonylphthalimides: Efficient synthesis, X-ray characterization, spectral investigations, POM analyses, DFT computations and antibacterial activity>, Safety of Morpholine-4-sulfonamide, the main research area is sulfonylphthalimide preparation antibacterial DFT; phthalic anhydride sulfonamide condensation ultrasonication.
Some novel N-sulfonylphthalimides I [R = NPh2, N-piperidinyl, morpholino, etc.] were synthesized in good yields by condensation of anhydride phthalic with various sulfonamides in one step. These compounds were screened for their antibacterial activity against E. coli, S. aureus, Morganella morganii and Klebsiella pneumoniae. So it will benificial to test these mols. against other biotargets different of bacterial strains such as viruses, fungus and parasites. The mol. structure of I [R = 3,4-dihydro-1H-isoquinolin-2-yl] was obtained by X-ray diffraction on mono crystal. The crystal packing could be described as alternating layers in zigzag parallel to (100) plane along the c axis, which were connected together with C-H···O hydrogen bonds.
Journal of Molecular Structure published new progress about Amines Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses) (sulfonyl-). 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Safety of Morpholine-4-sulfonamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics