Quality Control of tert-Butyl N,N’-diisopropylcarbamimidateIn 2019 ,《Intermolecular Heck Coupling with Hindered Alkenes Directed by Potassium Carboxylates》 appeared in Angewandte Chemie, International Edition. The author of the article were Huffman, Tucker R.; Wu, Yebin; Emmerich, Alexis; Shenvi, Ryan A.. The article conveys some information:
Pd0-catalyzed Mizoroki-Heck reactions traditionally exhibit poor reactivity with polysubstituted, unbiased alkenes. Intermol. reactions with simple, all-carbon tetrasubstituted alkenes are unprecedented. Herein we report that pendant carboxylic acids, combined with bulky monophospine ligands on palladium, can direct the arylation of tri- and tetrasubstituted olefins. Quaternary carbons are established at high Fsp3 attached-ring junctures and the carboxylate directing group can be removed after coupling. Carboxylate directivity prevents over-arylation of the new, less substituted alkene, which can be diversified in subsequent reactions. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Quality Control of tert-Butyl N,N’-diisopropylcarbamimidate)
tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Quality Control of tert-Butyl N,N’-diisopropylcarbamimidate
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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics