In 1995,Journal of Chemical Research, Synopses included an article by Casadei, Maria Antonietta; Cesa, Stefania; Inesi, Achille; Moracci, Franco Micheletti. Application of 4746-61-6. The article was titled 《Electrochemical studies on haloamides. Part 11. Electrocarboxylation of carboxamides》. The information in the text is summarized as follows:
The electroreduction of C2-unsubstituted and C2-mono- and -di-substituted haloacetamides XCR1R2CONHR3 (X = Br, Cl, R1, R2 = H, Me, R3 = PhCH2, Ph), carried out in dipolar aprotic solvents and in the presence of CO2, yields synthetically used malonamates R4O2CCR1R2CONHR3 (R4 = Me, Bu) following in situ alkylation. In the experiment, the researchers used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application of 4746-61-6)
2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Application of 4746-61-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics