Vejdelek, Zdenek; Rajsner, Miroslav; Svatek, Emil; Holubek, Jiri; Protiva, Miroslav published their research in Collection of Czechoslovak Chemical Communications on December 31 ,1979. The article was titled 《Benzocycloheptenes and heterocyclic analogs as potential drugs. XIV. Synthesis of 7-chloro-5-(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-2-(methylamino)-3H-1,4-benzodiazepine 4-oxide and of some related compounds》.Safety of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide The article contains the following contents:
The base-catalyzed condensation of 4-ClC6H4NO2 with 2-(cyanomethyl)-6,7,8,9-tetrahydro-5H-benzocycloheptene afforded the 2,1-benzisoxazole derivative I, which was reduced with Fe in AcOH to the ketone II. Its oxime was treated with ClCH2COCl in AcOH and gave 6-chloro-2-(chloromethyl)-4-(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)quinazoline 3-oxide. Treatment with MeNH2 in MeOH led to the substitution reaction with a simultaneous ring enlargement and the title compound III was formed. A similar reaction with 1-methylpiperazine proceeded without rearrangement resulting in the quinazoline derivative IV. III and IV were devoid of anticonvulsant activity. 7-Chloro-5-(6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-1,3-dihydro-1,4-benzodiazepin-2-one (mol. complex with II), 6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl 3′-(4-ethoxycarbonyl 4-phenylpiperidino)propyl ketone (an analog of pethidine devoid of analgetic activity), and intermediates useful in the synthesis of 5-(2-chlorophenyl)-7-ethyl-1,3-dihydrothieno[2,3-e]-1,4-diazepin-2-ones were also prepared In the experiment, the researchers used 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6Safety of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide)
2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide(cas: 50509-09-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Safety of 2-Amino-N-(3-(2-chlorobenzoyl)-5-ethylthiophen-2-yl)acetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics