Dean, Conor; Rajkumar, Sundaram; Roesner, Stefan; Carson, Nessa; Clarkson, Guy J.; Wills, Martin; Jones, Matthew; Shipman, Michael published the artcile< Readily accessible sp3-rich cyclic hydrazine frameworks exploiting nitrogen fluxionality>, Synthetic Route of 1192620-83-9, the main research area is cyclic hydrazine preparation enantioselective principal moment inertia.
Here, a strategy for the creation of sp3-rich, non-planar heterocyclic scaffolds e.g., I suitable for drug discovery is described that obviates the need to generate multiple stereogenic centers with independent control. Asym. transfer hydrogenation using a tethered Ru-catalyst is used to efficiently produce a range of enantiopure cyclic hydrazine building blocks (up to 99% ee) e.g., I. Iterative C-N functionalization at the two nitrogen atoms of these compounds produces novel hydrazine and hydrazide based chem. libraries e.g., I. Wide chem. diversification is possible through variation in the hydrazine structure, use of different functionalization chemistries and coupling partners, and controlled engagement of each nitrogen of the hydrazine in turn. Principal Moment of Inertia (PMI) anal. of this small hydrazine library reveals excellent shape diversity and three-dimensionality. NMR and crystallog. studies confirm that the frameworks prefer to orient their substituents in three-dimensional space under the control of a single stereogenic center through exploitation of the fluxional behavior of the two nitrogen atoms.
Chemical Science published new progress about Aromatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Synthetic Route of 1192620-83-9.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics