Wang, Yanwei; Liu, Hongxin; Li, Bin; Wang, Baiquan published the artcile< Rhodium(III)-catalyzed Intermolecular Unactivated Secondary C(sp3)-H Bond Amidation Directed by 3,5-dimethylpyrazole>, Application of C6H6ClNO2S, the main research area is pyrazole carboxamide preparation; sulfonyl urea preparation; alkylamide sulfonamine amidation rhodium catalyst.
A Rh(III)-catalyzed intermol. unactivated secondary C(sp3)-H bond amidation via nitrene insertion directed by 3,5-dimethylpyrazole has been reported. This procedure tolerates a broad substrate scope including chain and cyclic N-alkylamides, e.g., N-(sec-butyl)-3,5-dimethyl-1H-pyrazole-1-carboxamide. Notably, the directing group 3,5-dimethylpyrazole of chain N-alkylamide substrates could be easily removed via cascade intermol. amidation and intramol. cyclization in one-pot affording sulfonylureas such as I by increasing the reaction temperature
Advanced Synthesis & Catalysis published new progress about Amidation (regioselective). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application of C6H6ClNO2S.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics