Suleiman, Joseph Bagi; Nna, Victor Udo; Othman, Zaidatul Akmal; Zakaria, Zaida; Bakar, Ainul Bahiyah Abu; Mohamed, Mahaneem published the artcile< Orlistat attenuates obesity-induced decline in steroidogenesis and spermatogenesis by up-regulating steroidogenic genes>, Computed Properties of 96829-58-2, the main research area is orlistat spermatogenesis steroidogenesis epididymal malondialdehyde; DNA fragmentation; high-fat diet; obesity; orlistat; spermatogenesis; steroidogenesis.
We explored the possible preventive/therapeutic effects of orlistat (a medication prescribed for weight loss) on obesity-induced steroidogenesis and spermatogenesis decline. Twenty-four adult male Sprague Dawley rats weighing 250-300 g were randomized into four groups (n = 6/group), namely; normal control, high-fat diet, high-fat diet plus orlistat preventive group and high-fat diet plus orlistat treatment group. Orlistat was either concurrently administered with high-fat diet for 12 wk or administered from week 7-12 post- high-fat diet feeding. Obesity increased serum leptin and decreased adiponectin levels, decreased serum and intra-testicular levels of FSH, luteinising hormone and testosterone, sperm count, motility, viability, normal morphol. and epididymal antioxidants, but increased epididymal malondialdehyde level and sperm nDNA fragmentation. Further, the levels of steroidogenic acute regulatory protein protein and enzymic activities of CYP11A1, 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase were also significantly decreased in the testes of the high-fat diet group. Orlistat attenuated impaired spermatogenesis and steroidogenesis decline by up-regulating steroidogenic genes. This may not be unconnected to its significant effect in lowering serum leptin levels, since the hormone is known to dampen fertility potential. Therefore, orlistat may improve fertility potential in overweight/obese men.
Andrology published new progress about Adiponectins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Computed Properties of 96829-58-2.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics