Zhao, Jing; Zhang, Zhanwen; Nie, Dahong; Ma, Hui; Yuan, Gongjun; Su, Shu; Liu, Shaoyu; Liu, Sheng; Tang, Ganghua published the artcile< PET imaging of hepatocellular carcinomas: 18F-fluoropropionic acid as a complementary radiotracer for 18F-fluorodeoxyglucose>, Formula: C29H53NO5, the main research area is F-fluorodeoxyglucose (F-FDG); F-fluoropropionic acid (F-FPA); hepatocellular carcinoma (HCC); positron emission tomography (PET).
Objective: To evaluate the preclin. value of 18F-fluoropropionic acid (18F-FPA) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomog. (PET) for imaging HCCs. Methods: The 18F-FPAand 18F-FDGuptake patterns in 3HCCcell lines (Hep3B,HepG2, and SK-Hep1) were assessed in vitro and in vivo. The 18F-FPAuptakemechanismwas investigated using inhibition experimentswith orlistat and 5-tetradecyloxy-2-furoic acid.The 18F-FPAPET imagingwas performed in different tumor animalmodels and compared with 18F-FDG.We also evaluated the expressions of glucose transporter-1 (GLUT1), fatty acid synthase (FASN), and matrix metalloproteinase-2 (MMP2) in these cell lines. Results: In vitro experiments showed that the radiotracer uptake patterns were complementary in the HCC cell lines. Orlistat and 5-tetradecyloxy-2-furoic acid decreased the uptake of 18F-FPA. The tumor-to-liver ratio of 18F-FPA was superior to that of 18F-FDG in the SK-Hep1 and HepG2 tumors (P < .05). However, in the Hep3B tumors, the tumor-to-liver normalized uptake of 18F-FDG was higher than 18F-FPA (P < .01). FASN was highly expressed in cell lines with high 18F-FPA uptake, whereas GLUT1 was highly expressed in cell lines with high 18F-FDG uptake. The 18F-FPA uptake correlated with FASN (r = 0.89, P = .014) and MMP2 (r = 0.77, P = .002) expressions. Conclusions: PET imaging with 18F-FPA combined with 18F-FDG can be an alternative for detecting HCC. Molecular Imaging published new progress about 96829-58-2. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Formula: C29H53NO5.
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