Singh, Imocha Rajkumar; Mitra, Sivaprasad published the artcile< Interaction of chlorpropamide with serum albumin: Effect on advanced glycated end (AGE) product fluorescence>, HPLC of Formula: 94-20-2, the main research area is chlorpropamide blood albumin interaction advanced glycated end product fluorescence; AGE product; Chlorpropamide; Diabetes; Fluorescence quenching; Serum albumin.
Carrier proteins like bovine or human serum albumin (BSA and HSA, resp.) are prone to glycation as compared to the other available proteins. Reducing sugars such as L-arabinose (ara), D-(-) galactose (gal) and D-(-) fructose (fru) were used to create model glycated serum albumins and binding ability of these with known antidiabetic drug chlorpropamide (CPM) was monitored. Fluorescence quenching experiment revealed that interaction of CPM with native as well as glycated albumins undergoes through a ground state complex formation. CPM binds strongly to glycated HSA with arabinose (gHSAara) as compared to other glycated systems and to the native proteins. CPM interacts through Van der Waals and hydrogen bonding interaction to glycated BSA by D-(-) fructose (gBSAfru) and also with native HSA; whereas, it’s interaction with BSA and others glycated systems like gBSAara, gBSAgal and gHSAara occurs primarily through hydrophobic interaction. CPM showed an enhancement in the production of the advanced glycated end products (AGE) in all the glycated proteins. The difference in the binding capability of CPM to differently glycated albumins could be a major model to understand the drug carrying capacity of the glycated serum albumins.
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Advanced glycosylation end products Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, HPLC of Formula: 94-20-2.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics