Winters, Michael P.; Crysler, Carl; Subasinghe, Nalin; Ryan, Declan; Leong, Lynette; Zhao, Shuyuan; Donatelli, Robert; Yurkow, Edward; Mazzulla, Marie; Boczon, Lisa; Manthey, Carl L.; Molloy, Christopher; Raymond, Holly; Murray, Lynne; McAlonan, Laura; Tomczuk, Bruce published the artcile< Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor>, Application of C4H10N2O3S, the main research area is arylindolebutanamide alkylsulfonyl arylsulfonyl aminosulfonyl preparation CXCR2 antagonist.
A series of novel acylsulfonamide, acylsulfamide, and sulfonylurea bioisosteres of carboxylic acids were prepared as CXCR2 antagonists. Structure-activity relationships are reported for these series. The potent orally bioavailable inhibitor I had excellent PK properties and was active in a lung injury model in hyperoxia-exposed newborn rats.
Bioorganic & Medicinal Chemistry Letters published new progress about CXC chemokine receptor CXCR2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 25999-04-6 belongs to class amides-buliding-blocks, and the molecular formula is C4H10N2O3S, Application of C4H10N2O3S.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics