Liu, Wenjie;Zhang, Xing;Knochenmuss, Richard;Siems, William F.;Hill, Herbert H. Jr. published 《Multidimensional Separation of Natural Products Using Liquid Chromatography Coupled to Hadamard Transform Ion Mobility Mass Spectrometry》. The research results were published in《Journal of the American Society for Mass Spectrometry》 in 2016.Synthetic Route of C17H27NO3 The article conveys some information:
A high performance liquid chromatograph (HPLC)was interfaced to an atm. drift tube ion mobility time of flight mass spectrometry. The power of multidimensional separation was demonstrated using chili pepper extracts The ambient pressure drift tube ion mobility provided high resolving powers up to 166 for the HPLC eluent. With implementation of Hadamard transform (HT), the duty cycle for the ion mobility drift tube was increased from <1% to 50%, and the ion transmission efficiency was improved by over 200 times compared with pulsed mode, improving signal to noise ratio 10 times. HT ion mobility and TOF mass spectrometry provide an addnl. dimension of separation for complex samples without increasing the anal. time compared with conventional HPLC. The experimental procedure involved many compounds, such as N-Vanillylnonanamide (cas: 2444-46-4) .
N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Synthetic Route of C17H27NO3 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics