Vegas-Suarez, Sergio;Aristieta, Asier;Requejo, Catalina;Bengoetxea, Harkaitz;Lafuente, Jose Vicente;Miguelez, Cristina;Ugedo, Luisa published 《The effect of 5-HT1A receptor agonists on the entopeduncular nucleus is modified in 6-hydroxydopamine-lesioned rats》. The research results were published in《British Journal of Pharmacology》 in 2021.Recommanded Product: N,2-Dihydroxybenzamide The article conveys some information:
L-DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5-HT1A receptors. Since the internal segment of the globus pallidus, homologous to the entopeduncular nucleus in rodents, seems to be involved in the etiopathol. of L-DOPA-induced dyskinesia, we investigated whether the entopeduncular nucleus is modulated by the 5-HT1A receptor partial and full agonists, buspirone, and 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) in control and 6-hydroxydopamine (6-OHDA)-lesioned rats with or without long-term L-DOPA treatment. Extracellular single-unit electrocorticogram and local field potential recordings under anesthesia, immunostaining assays and optogenetic manipulation coupled to electrophysiol. recordings were performed. Systemic buspirone reduced the entopeduncular nucleus firing rate in the sham animals and burst activity in the 6-OHDA-lesioned rats (with or without L-DOPA treatment), while local administration reduced entopeduncular nucleus activity in all the groups, regardless of DA integrity. Systemic 8-OH-DPAT also induced inhibitory effects only in the sham animals. Effects triggered by buspirone and 8-OH-DPAT were reversed by the 5-HT1A receptor antagonist, WAY-100635. Neither buspirone nor 8-OH-DPAT modified the low-frequency oscillatory activity in the entopeduncular nucleus or its synchronization with the motor cortex. Buspirone did not alter the response induced by subthalamic nucleus opto-stimulation in the entopeduncular nucleus. Systemic 5-HT1A receptor activation elicits different effects on the electrophysiol. properties of the entopeduncular nucleus depending on the integrity of the nigrostriatal pathway and it does not alter the relationship between subthalamic nucleus and entopeduncular nucleus neuron activity. To complete the study, the researchers used N,2-Dihydroxybenzamide (cas: 89-73-6) .
N,2-Dihydroxybenzamide(cas: 89-73-6) is a hydroxamic acid that inhibits the activity of p-hydroxybenzoic acid (PHBA) reductase, an enzyme involved in the conversion of PHBA to benzoic acid. Recommanded Product: N,2-Dihydroxybenzamide The compound has been shown to inhibit mitochondrial membrane potential and mitochondrial functions, leading to cell death.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics