Takahashi, Bitoku et al. published new progress in experiments with the help of cas: 329-89-5

6-Aminonicotinamide (cas:329-89-5)COA of Formula: C6H7N3O is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.

Takahashi, Bitoku;Funami, Hideaki;Shibata, Makoto;Maruoka, Hiroshi;Koyama, Makoto;Kanki, Satomi;Muto, Tsuyoshi published 《Structural optimization of ghrelin receptor inverse agonists to improve lipophilicity and avoid mechanism-based CYP3A4 inactivation》 in 2015. The article was appeared in 《Chemical & Pharmaceutical Bulletin》. They have made some progress in their research.COA of Formula: C6H7N3O The article mentions the following:

Structural optimization of 2-aminonicotinamide derivatives as ghrelin receptor inverse agonists is reported. So as to avoid mechanism-based inactivation (MBI) of CYP3A4, 1,3-benzodioxol ring of the lead compound was modified. Improvement of the main activity and lipophilicity was achieved simultaneously, leading to compound 18a, which showed high lipophilic ligand efficiency (LLE) and low MBI activity. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)COA of Formula: C6H7N3O is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics