Hossen, Amjad Md.;Reza, A. S. M. Ali;Ahmed, A. M. Abu;Islam, Kamrul Md.;Jahan, Israt;Hossain, Rahni;Khan, Mohammad Forhad;Maruf, Mohammad Rifat Alam;Haque, Areeful Md.;Rahman, Atiar Md. published 《Pretreatment of Blumea lacera leaves ameliorate acute ulcer and oxidative stress in ethanol-induced Long-Evan rat: A combined experimental and chemico-biological interaction》 in 2021. The article was appeared in 《Biomedicine & Pharmacotherapy》. They have made some progress in their research.Safety of cis-13-Docosenamide The article mentions the following:
Blumea lacera (Burm.f.) DC. is described as a valuable medicinal plant in various popular systems of medicine. The aim of the experiment reports the in vivo antiulcer activity of methanol extract of Blumea lacera (MEBLL) and in silico studies of bioactive constituents of MEBLL. In this study, fasted Long-Evans rat treated with 80 % ethanol (0.5 mL) to induce gastric ulcer, were pretreated orally with MEBLL at different doses (250 and 500 mg/kg, p.o., b.w) and omeprazole (20 mg/kg, p.o.) and distilled water were used as a reference drug and normal control resp. In silico activity against gastric H+-K+ATPase enzyme was also studied. The findings demonstrated that the treatment with MEBLL attenuated markedly ulcer and protected the integrity of the gastric mucosa by preventing the mucosal ulceration altered biochem. parameters of gastric juice such total carbohydrate, total protein and pepsin activity. Addnl., the exptl. groups significantly (p < 0.001) inhibited gastric lesions and malondealdehyde (MDA) levels and upregulated antioxidant enzymes level. Furthermore, nine compounds were documented as bioactive, displayed good binding affinities to against gastric H+-K+ATPase enzyme while these compounds illustrated inhibitory effect. From these studies, it is established MEBLL has ulcer healing property as unveiled by in vivo and in silico studies.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.
cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Safety of cis-13-Docosenamide It is commonly used as a slip additive in the plastic manufacturing industry.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics