Ren, Fang;Yang, Xiao;Hu, Zhong-Wen;Wong, Vincent Kam Wai;Xu, Hong-Yan;Ren, Ji-Hua;Zhong, Shan;Jia, Xiao-Jiong;Jiang, Hui;Hu, Jie-Li;Cai, Xue-Fei;Zhang, Wen-Lu;Yao, Fang-Long;Yu, Hai-Bo;Cheng, Sheng-Tao;Zhou, Hong-Zhong;Huang, Ai-Long;Law, Betty Yuen Kwan;Chen, Juan published 《Niacin analogue, 6-Aminonicotinamide, a novel inhibitor of hepatitis B virus replication and HBsAg production.》. The research results were published in《EBioMedicine》 in 2019.SDS of cas: 329-89-5 The article conveys some information:
BACKGROUND: Hepatitis B surface antigen (HBsAg) is one of the important clinical indexes for hepatitis B virus (HBV) infection diagnosis and sustained seroconversion of HBsAg is an indicator for functional cure. However, the level of HBsAg could not be reduced by interferons and nucleoside analogs effectively. Therefore, identification of a new drug targeting HBsAg is urgently needed. METHODS: In this study, 6-AN was screened out from 1500 compounds due to its low cytotoxicity and high antiviral activity. The effect of 6-AN on HBV was examined in HepAD38, HepG2-NTCP and PHHs cells. In addition, the antivirus effect of 6-AN was also identified in mouse model. FINDINGS: 6-AN treatment resulted in a significant decrease of HBsAg and other viral markers both in vitro and in vivo. Furthermore, we found that 6-AN inhibited the activities of HBV SpI, SpII and core promoter by decreasing transcription factor PPARα, subsequently reduced HBV RNAs transcription and HBsAg production. INTERPRETATION: We have identified a novel small molecule to inhibit HBV core DNA, HBV RNAs, HBsAg production, as well as cccDNA to a minor degree both in vitro and in vivo. This study may shed light on the development of a novel class of anti-HBV agent. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .
6-Aminonicotinamide (cas:329-89-5)SDS of cas: 329-89-5 is an aminopyridine, which is a specific pentose inhibitor and thus inhibits the NADP production.It can be used as a reactant for the synthesis of 6-substituted imidazo[1,2-a]pyridines with potential application as chemotherapeutic drugs.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics