Formula: C17H27NO3《Rapid Screening for Exposure to “Non-Target” Pharmaceuticals from Wastewater Effluents by Combining HRMS-Based Suspect Screening and Exposure Modeling》 was published in 2016. The authors were Singer, Heinz P.;Wossner, Annika E.;McArdell, Christa S.;Fenner, Kathrin, and the article was included in《Environmental Science & Technology》. The author mentioned the following in the article:
Active pharmaceutical ingredients (APIs) have raised considerable concern over the past decade due to their widespread detection in water resources and their potential to affect ecosystem health. This triggered many attempts to prioritize the large number of known APIs to target monitoring efforts and testing of fate and effects. However, so far, a comprehensive approach to screen for their presence in surface waters has been missing. We explore a combination of an automated suspect screening approach based on liquid chromatog. coupled to high-resolution mass spectrometry and a model-based prioritization using consumption data, readily predictable fate properties and a generic mass balance model for activated sludge treatment to comprehensively detect APIs with relevant exposure in wastewater treatment plant effluents. The procedure afforded the detection of 27 APIs that had not been covered in our previous target method, which included 119 parent APIs. The newly detected APIs included 7 compounds with a high potential for bioaccumulation and persistence, and also 3 compounds that were suspected to stem from point sources rather than from consumption as medicines. Anal. suspect screening proved to be more selective than model-based prioritization, making it the method of choice for focusing anal. method development or fate and effect testing on those APIs most relevant to the aquatic environment. However, we found that state-of-the-practice exposure modeling used to predict potential high-exposure substances can be a useful complement to point toward oversights and known or suspected detection gaps in the anal. method, most of which were related to insufficient ionization. And N-Vanillylnonanamide (cas: 2444-46-4) was used in the research process.
N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Formula: C17H27NO3 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics