Reference of 1129-26-6,Some common heterocyclic compound, 1129-26-6, name is 4-Methoxybenzenesulfonamide, molecular formula is C7H9NO3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: N-acyl-indoline 1 (0.15mmol), amide 2 (0.3mmol), [RhCp*Cl2]2 (5mol%), AgOTf (20mol%), AgOAc (20mol%), PhI(OAc)2 (0.15mmol), HOAc(0.45mmol) and DCE (1.5 mL) were added into the tube and sealed. The reaction vessel was evacuated and back filled with N2 in three times. The reaction mixture was vigorously stirred at 100 C for 16 h. Then, the solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography on silica gel to give the desired product.
The synthetic route of 1129-26-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Dong, Yaqun; Sun, Song; Yu, Jin-tao; Cheng, Jiang; Tetrahedron Letters; vol. 60; 20; (2019); p. 1349 – 1352;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics