Safety of Diphenylmethanamine. Recently I am researching about NUCLEOTIDE-BINDING-SITES; MULTIDRUG-RESISTANCE; AUTOMATED DOCKING; DRUG-RESISTANCE; FLEXIBLE LIGANDS; TRANSPORT; OPTIMIZATION; PURIFICATION; MTT; CHEMORESISTANCE, Saw an article supported by the National Institute of General Medical Sciences (NIH/NIGMS)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R15 GM094771-02]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wise, JG; Nanayakkara, AK; Aljowni, M; Chen, G; De Oliveira, MC; Ammerman, L; Olengue, K; Lippert, AR; Vogel, PD. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine
Overexpression of ABC transporters like P-glycoprotein (P-gp) has been correlated with resistances in cancer chemotherapy. Intensive efforts to identify P-gp inhibitors for use in combination therapy have not led to clinically approved inhibitors to date. Here, we describe computational approaches combined with structure-based design to improve the characteristics of a P-gp inhibitor previously identified by us. This hit compound represents a novel class of P-gp inhibitors that specifically targets and inhibits P-gp ATP hydrolysis while not being transported by the pump. We describe here a new program for virtual chemical synthesis and computational assessment, ChemGen, to produce hit compound variants with improved binding characteristics. The chemical syntheses of several variants, efficacy in reversing multidrug resistance in cell culture, and biochemical assessment of the inhibition mechanism are described. The usefulness of the computational predictions of binding characteristics of the inhibitor variants is discussed and compared to more traditional structure-based approaches.
Welcome to talk about 91-00-9, If you have any questions, you can contact Wise, JG; Nanayakkara, AK; Aljowni, M; Chen, G; De Oliveira, MC; Ammerman, L; Olengue, K; Lippert, AR; Vogel, PD or send Email.. Safety of Diphenylmethanamine
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics