An article Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders WOS:000469304500004 published article about CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; CAMP-SPECIFIC PHOSPHODIESTERASE; LONG-TERM-MEMORY; PROTEIN-KINASE; MOLECULAR-MECHANISMS; ADENYLYL-CYCLASE; STRUCTURAL BASIS; AMP PRODUCTION; KNOCKOUT MICE; DROSOPHILA in [Gurney, Mark E.; Nugent, Richard A.; Mo, Xuesheng; Sindac, Janice A.] Tetra Discovery Partners Inc, 38 Fulton St West, Grand Rapids, MI 49503 USA; [Hagen, Timothy J.] Northern Illinois Univ, Dept Chem & Biochem, 1425 West Lincoln Highway, De Kalb, IL 60115 USA; [Fox, David, III] Beryllium Discovery Corp, 7869 NE Day Rd West, Bainbridge Isl, WA 98110 USA; [O’Donnell, James M.; Zhang, Chong; Xu, Ying] SUNY Buffalo, Dept Pharmaceut Sci, Sch Pharm & Pharmaceut Sci, Buffalo, NY 14214 USA; [Zhang, Han-Ting] West Virginia Univ, Hlth Sci Ctr, Rockefeller Neurosci Inst, Dept Behav Med & Psychiat, 1 Med Ctr Dr, Morgantown, WV 26506 USA; [Zhang, Han-Ting] West Virginia Univ, Hlth Sci Ctr, Rockefeller Neurosci Inst, Dept Physiol Pharmacol & Neurosci, 1 Med Ctr Dr, Morgantown, WV 26506 USA; [Groppi, Vincent E.] Univ Michigan, Michigan Drug Discovery, Life Sci Inst, 210 Washtenaw Ave, Ann Arbor, MI 48103 USA; [Bailie, Marc] INDS Inc, 6111 Jackson Rd,Suite 100, Ann Arbor, MI 48103 USA; [White, Ronald E.] White Global Pharma Consultants, 31 Kinglet Dr, South Cranbury, NJ 08512 USA; [Romero, Donna L.] Pharma Vat Consulting LLC, 1201 Turnberry Ridge Court, Chesterfield, MO 63005 USA; [Vellekoop, A. Samuel; Walker, Joel R.; Surman, Matthew D.; Zhu, Lei; Campbell, Robert F.] Albany Mol Res Inc, 21 Corp Circle, Albany, NY 12203 USA; [Fox, David, III] UCB Pharma, 7869 NE Day Rd West, Bainbridge Isl, WA 98110 USA; [Zhang, Chong] Janssen China R&D, 65 Guiqing Rd,Bldg A,Floor 6, Shanghai 200233, Peoples R China; [Campbell, Robert F.] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA in 2019.0, Cited 81.0. Computed Properties of C8H11NO. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9
Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis. The design and optimization of lead compounds was based on iterative analysis of X-ray crystal structures combined with metabolite identification. Selectivity for the activated, dimeric form of PDE4D provided potent memory enhancing effects in a mouse model of novel object recognition with improved tolerability and reduced vascular toxicity over earlier PDE4 inhibitors that lack subtype selectivity. The lead compound, 28 (BPN14770), has entered midstage, human phase 2 clinical trials for the treatment of Fragile X Syndrome.
Computed Properties of C8H11NO. Bye, fridends, I hope you can learn more about C8H11NO, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics