127828-22-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 127828-22-2 name is tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a chilled solution (-15 C) of 2 (1.41 g, 4.61 mmol) in THF (20 mL) was added N-methylmorpholine (NMM; 0.51 mL, 4.61 mmol) and subsequently isobutylchloroformate (IBCF; 0.61 mL, 4.61 mmol) under N2 atmosphere. After 5 min, a solution of 1 (0.857 g, 4.19 mmol) in THF (10 mL) was added dropwise at the same temperature, and the mixture was stirred for 30 min at the same temperature and then at room temperature for 1 h. After removing the solvent in vacuo, the residue was dissolved in ethyl acetate (50 mL). The organic phase was washed with 5% NaHCO3 (30 mL ¡Á 2), 5% citric acid (30 mL ¡Á 3), saturated NaCl solution (30 mL ¡Á 1), successively and dried over anhydrous MgSO4. After removal of the solvent in vacuo, the residue was subjected to flash chromatography on silica gel using a mixture of chloroform/methanol (100:1) as an eluent to provide 3 as a pale yellow solid (1.67 g, 80.6%) melting at 128-129 C. 1H NMR (CDCl3): delta 1.44 (9H, s, Boc), 3.17-3.51 (10H, overlapped, CH2), 4.76-4.78 (1H, dd, CH), 6.89 (1H, d, NH), 7.35-7.37 (2H, d, aromatic), 8.14-8.16 (2H, d, aromatic). ESI-MS (M+Na)+: m/z 515, found: 515. Anal. Calcd for C20H27N4O7F3: C, 48.78; H, 5.53; N, 11.38. Found: C, 48.46; H, 5.30; N, 11.21.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (2-(2-aminoethoxy)ethyl)carbamate, and friends who are interested can also refer to it.
Reference:
Article; Suzuki, Hiroyuki; Kanai, Ayaka; Uehara, Tomoya; Guerra Gomez, Francisco L.; Hanaoka, Hirofumi; Arano, Yasushi; Bioorganic and Medicinal Chemistry; vol. 20; 2; (2012); p. 978 – 984;,
Amide – Wikipedia,
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