Recently I am researching about NECROSIS-FACTOR-ALPHA; PHARMACOLOGICAL EVALUATION; HYBRID COMPOUNDS; PLATELETS; DESIGN; ASSAY, Saw an article supported by the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/23461-3, 2015/19531-1]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [135821/2011-8]. Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Chelucci, RC; de Oliveira, IJ; Barbieri, KP; Lopes-Pires, ME; Polesi, MC; Chiba, DE; Carlos, IZ; Marcondes, S; Dos Santos, JL; Chung, MC. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol. Recommanded Product: 2-(4-Aminophenyl)ethanol
Sickle Cell Anemia (SCA) is one of the most prevalent hereditary hematological diseases worldwide. The disease is characterized by chronic inflammation, hypercoagulable state, and pro-thrombotic profile, which lead the vaso-occlusive process. In this work, we described the antiplatelet activity and the ability to reduce tumor necrosis factor-alpha (TNF-) levels of phthalimide derivatives. All compounds inhibited platelet aggregation induced by collagen and adenosine diphosphate, at levels ranging from 26.0 to 74.2% and 30.7 to 79.6%, respectively. The compounds exhibited reduced bleeding time compared to acetylsalicylic acid (ASA). Moreover, compounds 4c and 10c inhibited TNF- levels at 73.5% and 65.0%, respectively. These findings suggest that phthalimide derivatives 4c and 10c are promising lead compounds useful to prevent vaso-occlusion and inflammation associated with the sickle cell anemia. [GRAPHICS] .
About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Chelucci, RC; de Oliveira, IJ; Barbieri, KP; Lopes-Pires, ME; Polesi, MC; Chiba, DE; Carlos, IZ; Marcondes, S; Dos Santos, JL; Chung, MC or concate me.. Recommanded Product: 2-(4-Aminophenyl)ethanol
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics