Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13304-62-6, name is N-Benzylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 13304-62-6
A mixture of 11-iodo-7,12-dihydropyrido[2?,3?:2,3]azepino[4,5-b]indol-6(5H)-one (11 b, 200mg, 0.530mmol), N-benzylacrylamide (95mg, 0.59mmol), triethylamine (101mg, 1.00mmol, 0.14mL), and Pd(OAc)2 (7mg, 0.03mmol) in DMF (3 mL) was heated for 40 min to 100 C in a sealed microwave reaction vial by means of a mono mode microwave device (100 W, 150 PSI, CEM Discover, CEM GmbH, Kamp-Lintfort, Germany). After cooling to room temperature the mixture was filtered through a charcoal frit. Upon addition of ethyl acetate (220 mL) to the filtrate a precipitate formed, which was filtered off and was washed on the frit with n-hexane (320 mL). In the combined washing layers more precipitate formed, which was also filtered off. The combined precipitates were crystallized from ethanol to yield a brown solid (49.0 mg, 22.7%); dec. starting at 226 C; IR (KBr): 3423 (NH), 2918 (CH aliphat.), 1655 (C=O), 1441, 1350 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 11.95 (s, 1H), 10.38 (s, 1H), 8.64 (t, 1H, 3JH,H = 6.0 Hz), 8.44 (dd, 1H, 3JH,H = 4.7 Hz, 4JH,H = 1.7 Hz), 8.36 (dd, 1H, 3JH,H = 7.9Hz, 4JH,H = 1.8 Hz), 8.23 (d, 1H, 3JH,H = 15.5 Hz), 7.95 (s, 1H), 7.75 (dd, 1H, 3JH,H= 7.8 Hz, 4JH,H = 0.9 Hz), 7.59 – 7.45 (m, 1H), 7.44 – 7.30 (m, 4H), 7.32 – 7.20 (m, 1H), 7.22 – 7.09 (m, 1H), 6.86 (d, 1H, 3JH,H = 15.6 Hz), 4.46 (d, 2H, 3JH,H = 5.9Hz), 3.63 (s, 2H); 13C NMR (100.6 MHz, DMSO-d6): delta = 171.4, 165.2, 162.3, 147.7, 139.4, 136.6, 131.2, 127.4, 117.6, 108.4 (quat C); 147.6, 136.3, 134.5, 128.3 (2C), 127.4 (2C), 126.8, 122.1, 119.5, 119.5, 119.3, 119.0 (tert C); 42.3, 35.7 (sec C); C25H20N4O2 (408.45); MS (EI): m/z = 408 ([M]+, 95), 301 (52), 274 ([C17H12N3O]+, 21), 259 (100); HRMS (EI): m/z ([M]+) calcd. 408.15808, found 408.15883; HPLC: 96.8% at 254 nm, 97.1% at 280 nm, tN = 6.4 min, tM = 1.09 min (ACN/H2O; 40:60), max = 269, 338 nm.
According to the analysis of related databases, 13304-62-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Maiwald, Franziska; Benitez, Diego; Charquero, Diego; Dar, Mahin Abad; Erdmann, Hanna; Preu, Lutz; Koch, Oliver; Hoelscher, Christoph; Loaec, Nadege; Meijer, Laurent; Comini, Marcelo A.; Kunick, Conrad; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 274 – 283;,
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