In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141449-85-6 as follows. category: amides-buliding-blocks
A flask was charged with tert-butyl octahydropyrrolo[3,4-c]pyrrole-2-carboxylate (1.20 g, 5.65 mmol, 1.00 equiv), potassium (bromomethyl)trifluoroboranuide (1.13 g, 5.63 mmol, 1.00 equiv), and THF (15 mL) under nitrogen. The mixture was stirred overnight at 80 C and concentrated under reduced pressure. Potassium carbonate (0.781 g, 5.65 mmol, 1.00 equiv) and acetone (10 mL) were added. The resulting solution was stirred for 2 h at room temperature, dissolved in acetone (2 x 200 mL) and filtered. The filtrate was concentrated under reduced pressure to provide 1.40 g (75% yield) of potassium ((5-(tert- butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(lH)-yl)methyl)trifluoroborate as a yellow solid. LCMS (ESI, m/z): 293 [M-K]”.
According to the analysis of related databases, 141449-85-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABIDE THERAPEUTICS, INC.; GRICE, Cheryl A.; WIENER, John J. M.; WEBER, Olivia D.; DUNCAN, Katharine K.; (364 pag.)WO2018/217805; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics