Synthetic Route of 177906-48-8, The chemical industry reduces the impact on the environment during synthesis 177906-48-8, name is trans-N-Boc-1,4-cyclohexanediamine, I believe this compound will play a more active role in future production and life.
Method E The reaction mixture of Core C (1.00 eq) and amine n (4.00 eq) in DMSO (8 mL) was stirred at 160 C for 3 h. The reaction mixture was cooled to rt and poured onto ice-H20 (20 mL). The aqueous layer was extracted with EA (50 mL*3). The combined organic layers were washed with brine (50 mL*3), dried over Na2S04, filtered and concentrated. The residue was purified by column chromatography to give A-n. Step 1: Compound 27_2 was made according to the procedure descibed in method E with amine-27 (1.0 eq) and DIEA (10 eq) at 160C for 6 h and it was obtained as a yellow solid after purification by prep HPLC (TFA). Yield: 41.1% NMR (CDCb, 400 MHz) delta 8.18 (d, / = 5.2 Hz, 1H), 7.83 (s, 1H), 6.71 (d, / = 5.6 Hz, 1H), 4.87 (s, 1H), 4.41 (s, 1H), 3.89 – 3.82 (m, 4H), 3.49 (s, 1H), 3.19 (d, / = 6.3 Hz, 2H), 2.19 – 2.05 (m, 4H), 1.46 (s, 9H), 1.35 – 1.29 (m, 7H), 1.26 (m, 2H), 1.23 (m, 2H), 0.50 – 0.46 (m, 2H), 0.26 – 0.24 (m, 2H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, trans-N-Boc-1,4-cyclohexanediamine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD; BEN NERIAH, Yinon; BRACHYA, Guy; BURSTAIN, Ido; MINZEL, Waleed; SNIR-ALKALAY, Irit; VACCA, Joseph; LI, Dansu; (129 pag.)WO2017/21969; (2017); A1;,
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