I found the field of Chemistry very interesting. Saw the article Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification published in 2020.0. Quality Control of Diphenylmethanamine, Reprint Addresses Cink, RD (corresponding author), AbbVie Inc, Proc Res & Dev, N Chicago, IL 60064 USA.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine
Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical trials and subsequent commercial launch. The large-scale synthetic route to glecaprevir required the development of completely new synthetic approaches to the two key structural features: the 18-membered macrocycle 3 and the difluoromethyl-substituted cyclopropyl amino acid 4. In this first manuscript, we describe the route development for the macrocycle 3; the second manuscript will describe the development of a new synthetic route to the difluoromethyl-substituted cyclopropyl amino acid 4 and the final assembly of glecaprevir. The large-scale synthetic route to the macrocycle employed a unique intramolecular etherification reaction as the key step in the macrocycle synthesis, avoiding the scalability limitations of the ring-closing metathesis (RCM) reaction of the enabling route. The large-scale synthetic route to the macrocycle was successfully used to produce the amount of glecaprevir required to support the late-stage clinical development.
About Diphenylmethanamine, If you have any questions, you can contact Kallemeyn, JM; Engstrom, KM; Pelc, MJ; Lukin, KA; Morrill, WH; Wei, HJ; Towne, TB; Henle, J; Nere, NK; Welch, DS; Shekhar, S; Ravn, MM; Zhao, G; Fickes, MG; Ding, C; Vinci, JC; Marren, J; Cink, RD or concate me.. Quality Control of Diphenylmethanamine
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics