In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2895-21-8 as follows. HPLC of Formula: C5H10ClNO
General procedure: The corresponding CH-acid 1a-f (25 mmol) was dissolved in a solution of potassium hydroxide (1.4 g, 25 mmol) in ethanol (50 ml) at 10 C. In several cases after addition of 1 a precipitate was formed, which did not have an effect on the reaction conditions or the final product. After stirring for 1 min carbon disulfide (1.5 ml, 25 mmol) was added to the resulting solution, and the reaction mixture was stirred for 20 min. Water (10-15 ml) was added to the mixture to dissolve the resulting precipitate. Subsequently, ester 4 (3.4 ml, 25 mmol) in ethanol (20 ml) was added to the reaction mixture dropwise for 1 h, which was quenched with potassium hydroxide solution (2.8 g, 50 mmol) in ethanol (100 ml), after stirring for 10 min. The resulting reaction mixture was refluxed for 2.5 h. After cooling to room temperature, the solution was quenched with concentrated HBr (2.8 ml, 25 mmol), stirred for 30 min, and divided into five equal portions. Each portion was then reacted with the corresponding alkylhalide 8a-t (5 mmol) under refluxing conditions for 1 min. After cooling the reaction to room temperature, the resulting precipitate was filtered off and rinsed on the filter to give pure thieno[3,2-b]pyridines 9a-af in 58-88% yield.
According to the analysis of related databases, 2895-21-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Zubarev, Andrey A.; Shestopalov, Anatoliy M.; Larionova, Natalia A.; Rodinovskaya, Lyudmila A.; Shestopalov, Alexander A.; Tetrahedron; vol. 69; 46; (2013); p. 9648 – 9655;,
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