Electric Literature of 67442-07-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67442-07-3 as follows.
[0541] A mixture of N-(4-chlorobenzyl)-2-(hydroxymethyl)-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide (100 mg, 0.288 mmol), potassium carbonate (60 mg, 0.43 mmol) and 2-chloro-N-methoxy-N-methylacetamide (200 mg) in DMF (1.5 mL) was shaken at room temp. for 48 hrs. The mixture was diluted with water (5 mL), and the resulting solid was collected by filtration. The crude solid was recrystallized from aq. ethanol to afford title compound (90 mg). The title compound is also a compound of formula I. [0542] Physical characteristics are as follows: [0543] 1H NMR (400 MHz, DMSO-d6) delta) 10.45 (1H), 8.73 (1H), 7.37 (4H); 7.26 (1H), 5.91 (1H), 5.47 (2H), 4.74 (2H), 4.54 (2H), 3.86 (3H), 3.16 (3H); HPLC ret time=2.86 min; MS (ES+) m/z 450, 452.
According to the analysis of related databases, 67442-07-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Larsen, Scott D.; May, Paul; Romines, Karen; Schnute, Mark E.; Tanis, Steven P.; US2004/138449; (2004); A1;,
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