Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 71026-66-9, name is tert-Butyl (4-aminophenyl)carbamate, A new synthetic method of this compound is introduced below., name: tert-Butyl (4-aminophenyl)carbamate
2,4-dichloro-5-nitropyrimidine (190 mg, 0.98 mmol) 6 mL of 1,4-dioxane was added,Placed in a 25 mL round bottom flask, Stirred at room temperature,(4-aminophenyl)Tert-butyl carbamate(200 mg, 0.96 mmol),N,N-diisopropylethylamine (137 mg, 1.06 mmol)Dissolved in 4 mL of 1,4-dioxane, Slowly added dropwise to the above reaction solution,After the addition was continued, the mixture was stirred at room temperature for about 1 hour,TLC to monitor the complete conversion of the reaction.Rotary Evaporation In addition to solvent,The crude product was separated by silica gel column chromatography (petroleum ether / ethyl acetate = 10: 1, v / v)To give 301 mg of tert-butyl (4- (2-chloro-5-nitropyrimidine-4-amino) phenyl)carbamate as an orange solid in 82% yield.
The synthetic route of 71026-66-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; East China University of Science and Technology; LI, HONGLIN; XU, YUFANG; CHEN, ZHUO; ZHAO, ZHENJIANG; LU, JIANKUN; SUN, DEHENG; YANG, YU; ZHOU, WEI; (29 pag.)CN106467540; (2017); A;,
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