In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4141-08-6, name is 2-Amino-N-methylbenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: amides-buliding-blocks
2-amino-N-methylbenzamide (1.53 g, 10 mmol), potassium carbonate (2.07 g, 15 mmol), DMF (15 mL) were added in a 100 mL reaction flask, 2,4,5-trichloropyrimidine (1.85 g, 10 mmol) was added with stirring. The reaction solution was stirred at 75 C for 5 hours, the reaction solution was poured into water, and the solid precipitated, and the filter cake was collected by filtration. The filter cake was beaten with 50% acetonitrile-water and dried to give 2 g of pale yellow solid II-01 in 67% yield.
The synthetic route of 4141-08-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beijing Normal University; Zhang Huabei; Fang Yu; Wang Dawei; Qi Yueheng; Liu Jianping; Gao Hang; (43 pag.)CN106905303; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics