Adding a certain compound to certain chemical reactions, such as: 19982-07-1, name is N-(3,5-Dimethyladamantan-1-yl)acetamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19982-07-1, name: N-(3,5-Dimethyladamantan-1-yl)acetamide
[0063] 1.00 g (5.50 mmol) of 3,5-dimethyl-1-adamantanol, 0.46 g (11.1 mmol) of acetonitrile, and 9.61 g of mesitylenewere added to a test tube having an outer diameter of 30 mm to obtain a mixed solution. Then, 1.12 g (11.1 mmol) of97% concentrated sulfuric acid was dropped into the mixed solution in the test tube to obtain a reaction solution. Theobtained reaction solution was stirred at 30C for 3 hours to continue the reaction. Then, 6.09 g of water was added tothe reaction solution to stop the reaction, and an aqueous phase was removed by washing from the reaction solution toobtain a mesitylene solution containing 1-acetamido-3,5-dimethyladamantane (reaction yield: 80.4%). Then, 0.71 g ofsodium hydrate (NaOH) and 9.61 g of 1-hexanol were added to the obtained solution to obtain a reaction solution. The obtained reaction solution was stirred at 130C for 18 hours to hydrolyze 1-acetamido-3,5-dimethyladamantane. Then,in the reaction solution, the generation of memantine was confirmed by GC (reaction yield: 96.2%).
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Reference:
Patent; Mitsubishi Gas Chemical Company, Inc.; SHIMO, Tetsuya; EP2949643; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics