Adding a certain compound to certain chemical reactions, such as: 108468-00-4, name is 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108468-00-4, HPLC of Formula: C13H20N2O2
Step 1: l-(N-boc-aminomethyl)-4-(aminomethyl) benzene (3.80g, 16.1 mmol) wasdissolved in DCM (100 mL) and DIPEA (5.0 mL, 29 mmol), followed by FmocCl (5.Og, 19 mmol)were added. The reaction mixture was stirred at room temperature for 1 hour, after which aprecipitate appeared. Water (100 mL) was added and the precipitate filtered and dried to give [4- (tert-butoxycarbonylamino-methyl)-benzyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (6.32g, 86%) as a white solid. AnalpH2_MeOH_4MIN: Rt: 3.52 mm, mlz 481.3 [M+H]
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Reference:
Patent; UNIVERSITY OF LEEDS; PHILIPPOU, Helen; FOSTER, Richard; FISHWICK, Colin; REVILL, Charlotte; YULE, Ian; TAYLOR, Roger; NAYLOR, Alan; FALLON, Philip, Spencer; CROSBY, Stuart; HOPKINS, Anna; GUETZOYAN, Lucie, Juliette; MACNAIR, Alistair, James; STEWART, Mark, Richard; WINFIELD, Natalie, Louise; (273 pag.)WO2019/186164; (2019); A1;,
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