Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61903-11-5, name is 1-(1,4-Diazepan-1-yl)ethanone, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(1,4-Diazepan-1-yl)ethanone
A solution of lambda/-(7-chloro-2-methylpyrazolo[l,5-alpha]pyrimidin-5-yl)-4-(2- hydroxypropan-2-yl)benzamide (2F, 86 mg, 0.25 mmol) and l-(l,4-diazepan-l-yl)ethanone (101 mg, 0.75 mmol) in DMF (1.0 mL) was stirred at 100 0C for 2h. After cooling to room temperature, the mixture was diluted with a few drops of DMSO and methanol, and was then purified by preparatory HPLC (25-40% MeCN/H2O gradient + 0.01% TFA). Lyophilization of the combined fractions gave the titled compound as a white solid (87.7 mg, 78%). 1H NMR (DMSO-de) [1 :1 ratio of rotamers: delta: 10.93 (s, IH); 10.91 (s, IH)], 7.99 (d, J = 8.3 Hz, 2H), 7.62 (dd, 2H), [1 :1 ratio of rotamers: 7.13 (s, IH); 7.07 (s, IH)], [1 :1 ratio of rotamers: 6.19 (s, IH); 6.18 (s, IH)], [1 :1 ratio of rotamers: 4.37 (t, J = 5.6 Hz, 2H); 4.20 (t, J = 5.4 Hz, 2H)], [1 :1 ratio of rotamers: 4.03 (t, J = 5.6 Hz, 2H); 3.97 (t, J = 5.9 Hz, 2H)], 3.63 – 3.78 (m, 2H), [1 :1 ratio of rotamers: 3.58 (t, J = 5.9 Hz, 2H); 3.52 (t, J = 5.8 Hz, 2H)], 2.37 (s, 3H), [1 :1 ratio of rotamers: 2.03 – 2.11 (m, 2H); 1.94 (quin, J = 5.9 Hz, 2H)], [1 :1 ratio of rotamers: 2.02 (s, 3H); 1.89 (s, 3H)], 1.46 (s, 6H); ESI-MS: m/z 451.3 (M+H)+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/123986; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics