Reference of 2895-21-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2895-21-8, name is N-Isopropyl-2-chloroacetamide, This compound has unique chemical properties. The synthetic route is as follows.
To a stirred solution of 2-chloro-N-isopropylacetamide (602 mg, 4.44 mmol) and methyl 4-hydroxybenzoate (500 mg, 3.29 mmol) in DMF (18 mL) at r.t. under N2 was added potassium carbonate (1817 mg, 13.15 mmol) in a single portion. The mixture was heated at 80 ^C overnight, cooled and partitioned between EtOAc and H2O. The layers were separated and the aqueous layer was extracted with EtOAc (2×). The combined organics were washed with H2O and brine, dried (phase sep.) and concentrated to give crude methyl 4-[2-(isopropylamino)-2-oxo- ethoxy]benzoate (870 mg, 3.18 mmol, 97% yield). LC-MS (ES+, Method C): 2.32 min, m/z 252.0 [M+H]+
The chemical industry reduces the impact on the environment during synthesis N-Isopropyl-2-chloroacetamide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; REDX PHARMA PLC; JONES, Clifford, D.; BUNYARD, Peter; PITT, Gary; BYRNE, Liam; PESNOT, Thomas; GUISOT, Nicolas, E.S.; (318 pag.)WO2019/145729; (2019); A1;,
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