Synthetic Route of 337463-88-4, These common heterocyclic compound, 337463-88-4, name is 6-Bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
6-Bromo-4/-/-pyrido[3,2-b][1 ,4]oxazin-3-one (6.0 g, 26.3 mmole) and trans-2- phenylvinylboronic acid (3.9 g, 26.3 mmole) were dissolved in 1 ,4-dioxane (150 mL) and the solution was degassed with argon. (PhbetaP^Pd (230 mg, 0.2 mmole) was added, followed by a solution of potassium carbonate (6.9 g, 50 mmole) in H2O (20 mL). The reaction was heated at reflux under argon overnight, then was cooled to room temperature and diluted with EtOAc (200 mL). The solution was washed sequentially with H2O and brine, dried (Na2SO4), and concentrated in vacuo. The solid residue was purified by flash chromatography on silica gel (5-10% EtOAc/CHCl3) to afford a solid (2.5 g, 38%): LCMS(ES) m/z253.0 (M + H)+.
Statistics shows that 6-Bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one is playing an increasingly important role. we look forward to future research findings about 337463-88-4.
Reference:
Patent; GLAXO GROUP LIMITED; WO2006/81182; (2006); A2;,
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