Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 148017-28-1, name is tert-Butyl sulfamoylcarbamate, This compound has unique chemical properties. The synthetic route is as follows., category: amides-buliding-blocks
Step b: fert-Butyl (aminosulf onyl) f r(3aR,4R<6R,6aR)-6-(6-chloro-9H-purin-9-yl)- 2,2-dimethyltetrahydrofuror3,4-rfiri31dioxol-4-yl1memyl)carbamate; [0237] (2R/3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (6.352g, 0.01944mol), N-Boc-sulfamide (5.717g, 0.02913mol) and triphenylphosphine (6.119g, 0.02333mol) were dissolved in ethyl acetate (20OmL) under nitrogen and diisopropyl azodicarboxylate (5.742mL, 0.02916mol) was added dropwise. The solution was stirred for 2h, and then concentrated in vacuo. The residue was purified by flash chromatography (Hex/EtOAc 25% to 65%) to afford 5.46Og of product as a white solid and 1.4Og of product with triphenylphosphine oxide impurity. This second batch was purified by flash chromatography (Hex/EtOAc 20% to 60%). The product was obtained as a white solid (6.16Og, 63%).[0238] LCMS: R.t. 1.66 min ES+ 505 (formic acid).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 148017-28-1.
Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2006/84281; (2006); A1;,
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