Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 159326-71-3, name is Pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H5N3O
(Step 3) 4-chloropyrrolo[1,2-f][1,2,4]triazine; Diisopropylethylamine (3.5 mL, 20.3 mmol) was added to a solution of pyrrolo[1,2-f][1,2,4]triazin-4(3H)-one (2.5 g, 18.5 mmol) dissolved in toluene (37.5 mL) under nitrogen atmosphere. Subsequently, after adding phosphorus oxychloride (5.1 mL, 55.7 mmol), the mixture was heated for 20 hours at 100 C. The resulting reaction mixture was cooled to 0 C. and, after slowly adding sodium bicarbonate aqueous solution, stirred at room temperature for 30 minutes. The resulting aqueous layer was extracted with ethyl acetate, dried with magnesium sulfate, and then filtered. The filtrate was concentrated in vacuum. The resulting yellow solid product was subjected to the next step without purification (2.31 g, 15.0 mmol, 81% yield).1H NMR (400 MHz, CDCl3): 8.22 (s, 1H), 7.87 (dd, J=2.4 Hz, 1.6 Hz, 1H), 7.00-6.97 (m, 2H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 159326-71-3.
Reference:
Patent; NEOPHARM CO., LTD.; US2011/183983; (2011); A1;,
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