Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2603-10-3, name is Methyl N-Phenylcarbamate, A new synthetic method of this compound is introduced below., Quality Control of Methyl N-Phenylcarbamate
Aniline 4650 g, dimethyl carbonate 226.7 g,Zinc acetate 3.65 g in turn into the reactor,After replacing with nitrogen and pressurized to 0.2 Mpa, heated to 180 C,Reaction at this temperature for 5 h.After completion of the reaction, the temperature of the reactor was reduced to 80 C and constant temperature,To the autoclave, add 40 mL of concentrated hydrochloric acid,A constant-flow pump was added dropwise with an aqueous formaldehyde solution (40% by mass) at a dropping rate of 0.15 mL / min,The dropping time is 100 min. After completion of the dropwise addition, the reaction was continued at 80 C for 2 h.After completion of the reaction, the reaction solution was analyzed by high performance liquid chromatography,The yield of methyl 4,4′-diphenylmethane dicarbamate was 67%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Research Institute of Nanjing Chemical Industry Group; ina Petroleum & Chemical Corporation; JIN, YUCUN; JIN H, ANQIANG; WU, QIJIAN; CHEN, YONGPING; LIU, ZHUO; HE, YUMIAO; (4 pag.)CN106543038; (2017); A;,
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