Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54468-86-9, name is 2-Amino-N,N-dimethylbenzenesulfonamide, A new synthetic method of this compound is introduced below., category: amides-buliding-blocks
Compound c18-3 (1 g, 5 mmol) was placed in a 100 mL three-necked flask and added to N,N-dimethylformamide (20 mL).The ice salt bath was below 0 C, then sodium hydride (0.4 g, 10 mmol) was added and stirred for 15 minutes.Then a solution of compound b2 (0.86 mL, 10 mmol) in N,N-dimethylformamide was added and stirred at room temperature overnight.10mL of water was added, extracted with ethyl acetate, the organic phase was washed with saturated brine, dried over anhydrous magnesium sulfate,Concentration through the column gave 0.47 g of a white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Zhejiang Tongyuankang Pharmaceutical Co., Ltd.; Wu Yusheng; Zhi Wubin; Wang Xin; Wu Shiyong; Li Jingya; Guo Ruiyun; Zheng Maolin; Liang Apeng; Wang Guohui; Chen Mingtao; Ma Jie; Niu Chengshan; (65 pag.)CN108689994; (2018); A;,
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