Some common heterocyclic compound, 14062-80-7, name is 4-Chloro-N,N-dimethylbenzamide, molecular formula is C9H10ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C9H10ClNO
General procedure: To a mixture of 1a (0.6g, 4.8 mmol, 1equiv), imidazolium chloride (0.25g, 2.4 mmol,0.5equiv) and N,N-dimethylbenzamide (1.43g, 9.6 mmol, 2 equiv) was added. Themixture was stirred at 160C for 10h. after completion of the reaction. 15ml water was added and the resulting mixture was extracted with 20ml EA thrice, and the combined organic layers were dried over anhydrous Na2SO4 and concentrated. The residue was purified by column chromatography on silica gel using PE/EA as eluent to obtain thepure desired product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 14062-80-7, its application will become more common.
Reference:
Article; Tian, Qingqiang; Luo, Wen; Gan, Zongjie; Li, Dan; Dai, Zeshu; Wang, Huajun; Wang, Xuetong; Yuan, Jianyong; Molecules; vol. 24; 1; (2019);,
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