Synthetic Route of 99733-18-3,Some common heterocyclic compound, 99733-18-3, name is tert-Butyl (7-aminoheptyl)carbamate, molecular formula is C12H26N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: tert-butyl(3-aminopropyl)carbamate (3a,508 mg, 2.93 mmol)was added toa stirred solutionof4-aminobenzoic acid (2a, 200 mg, 1.46 mmol), EDCI (421mg, 2.20 mmol), HOBt(237 mg, 1.76 mmol), DIEA (502 muL, 2.92 mmol) in DMF (10 mL), stirred overnight at RT. After monitored by TLC to observe completion of reaction, the mixture was diluted with water (20 mL), and then the water phase was extracted with ethylacetate (20 mL¡Á2). The combined organic phase was washed with water (20 mL¡Á3)for three times and dried with anhydrous Na2SO4. The crude product was purified bysilica gel column chromatography to afford intermediates 5aa in 81% yield as whitesolid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (7-aminoheptyl)carbamate, its application will become more common.
Reference:
Article; Wang, Xin; Yu, Chenhua; Wang, Cheng; Ma, Yakun; Wang, Tianqi; Li, Yao; Huang, Zhi; Zhou, Manqian; Sun, Peiqing; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong; European Journal of Medicinal Chemistry; vol. 181; (2019);,
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