Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 147356-78-3, name is N-Methoxy-N-methylcyclopropanecarboxamide, A new synthetic method of this compound is introduced below., Formula: C6H11NO2
To the reaction flask, 2-(2-methoxyphenoxy)tetrahydropyran (8B) (200 g, 0.96 mol) and tetrahydrofuran (1000 ml) were added under nitrogenatmosphere, cooled to -20 C. with dry ice acetonebath, added nButyllithium(460 mL, 1.15 mol, 2.5M, Energy Chemical) dropwise slowly,stirred at -10 C. for 2 h. N-methyl-N-methoxyacetamide(186 g, 1.44 mol) was added and stirred at room temperature overnight. The reactionmixture was quenched with a saturated ammonium chloride solution (1000 mL), the organic phase was collected, washed with water (1000mL×2), brine (1000 mL×2), dried over anhydrous sodium sulfate and concentrated under vacuum to obtain cyclopropyl-(3-methoxy-2-tetrahydropyran-2-yloxy-phenyl)methanone (8C) as a red liquid (280 g, crude product), which was submitted to the next step without furtherpurification
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Sichuan Haisco Pharmaceutical Co., Ltd; Chin, Rinrin; Li, Fang chiong; Lee, Swi Swi; Luo, Huadong; Luo, Sin Pong; Wan, songrin; Ron, Ray; Liu, Guoliang; Wei, Yonggang; Liu, Chien Wi; Tang, Peongcho; (148 pag.)KR2016/5361; (2016); A;,
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