Synthetic Route of 10268-06-1, The chemical industry reduces the impact on the environment during synthesis 10268-06-1, name is 2-(2-Chlorophenyl)acetamide, I believe this compound will play a more active role in future production and life.
To a solution of compound methyl 2-(5-chloro-1–(2-fluoroethyl)-1H– indol?3?yl)?2-oxoacetate (200 mg, 0.710 mmol, 1.00 equiv.) and compound 2-(2-chlorophenyl)acetamide (132 mg, 0.780 mmol, 1.10 equiv.)in THF (10 mL, 0.071 M) was added with t-BuOK solution (190 mg, 1.69 mmol, 2.40 equivj/THF (5.00 mL) at 0 °C under nitrogen atmosphere. After the reaction mixture was stirred at 0 00 for another 5 h, it was quenched by iN HC1 (10.0 mL). The excess acid was neutralized by sodium bicarbonate. The solution was extracted with EtOAc (10 mL x3), washed with brine, dried with MgSO4, filtered, and concentrated in vacuo. The residue was purified through column chromatography using EtCAc:hexanes (1 : 1.5 (v/v)) to afford the title compound as a light yellow solid (64.8 mg, 0.161 rnm0l, 23percent yield). NMR Spectroscopy: ?H NMR (700 MHz, (CD3)2S0, 25 °C, ) : 11.22 (s, lH), 8.21 (s, lH), 7.58(d, J = 8.7 Hz, lH), 7.55 (d, J = 7.9 Hz, lH), 7.51?7.49 (m, 1H),7.41?7.40 (m, 2H), 7.13 (dd, J 2.0, 8.7 Hz, 1H), 6.19 (d, J 2.0Hz, 1H), 4.76 (t, J = 4.6 Hz, lH), 4.70 (t, J= 4.6 Hz, 1H), 4.65 (t,J 4.6 Hz, 1H), 4.60 (t, J = 4.6 Hz, 1H). 13C NMR (175 MHz, (CD3)2S0,25 °C, ) 171.7, 171.2, 135.7, 135.0, 134.2, 133.5, 132.2, 130.8,129.4, 127.6, 127.0, 126.2, 125.2, 122.2, 119.8, 112.4, 104.4, 83.0,82.0, 46.6 (d, J =19.9 Hz). Z9p NMR (376 MHz, (0D3)2S0, 25 °C, oe) -222.1 (m) . HRMS (ESI?TOF) (m/z) : calcd for C2flH14N2O2FC12 ( [M + H]),403.0416, found, 403.0408.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Chlorophenyl)acetamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK; NGAI, Ming-Yu; LEE, Katarzyna, N.; HU, Kongzhen; NASDEV, Neil; HAGGARTY, Stephen, J.; (120 pag.)WO2018/132636; (2018); A1;,
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