Related Products of 67442-07-3, These common heterocyclic compound, 67442-07-3, name is 2-Chloro-N-methoxy-N-methylacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1L three bottles of iodine was added 20g2–chloro-7-fluoro-9,9-fluorene and 500mLTHF, clear solution. Temperature of the system was cooled to -10 deg.] C, was added dropwise 41g18percent of isopropylmagnesium chloride in tetrahydrofuran was incubated for 1 hour. Then a solution of toluene solution 54g20percent of active amide. Incubated for 1 hour. End of the reaction, with 40g15percent hydrochloric acid quenched stratification. Toluene and the combined organic phases. Removing solvent gave the crude product was recrystallized from toluene to give 2-chloro-1- (7-chloro-9,9-difluoro-9H-fluoren-2-yl) ethanone15g, a yield of 86.8percent.
The synthetic route of 67442-07-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Wansu Chemicals Co., Ltd; Xu, Zhi; Wang, Shaobo; Sun, Zhongyue; Du, Weiping; (19 pag.)CN105237384; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics