Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 112-84-5, Name is Erucamide, SMILES is CCCCCCCC/C=CCCCCCCCCCCCC(N)=O, in an article , author is Chang, Miao-Ning, once mentioned of 112-84-5, Recommanded Product: Erucamide.
The retinoic acid receptor-related orphan receptor-gamma-t (ROR gamma t) is the master transcription factor responsible for regulating the development and function of T-helper 17 (Th17) cells, which are related to the pathology of several autoimmune disorders. Therefore, ROR(gamma)t is an attractive drug target for such Th17-mediated autoimmune diseases. A structure-activity relationship (SAR) study of lead compound 1 yielded a novel series of ROR(gamma)t inhibitors, represented by compound 6. Detailed SAR optimization, informed by X-ray cocrystal structure analysis, led to the discovery of a potent orally bioavailable ROR(gamma)t inhibitor 25, which inhibited IL-17 production in the skin of IL-23-treated mice by oral administration.
Interested yet? Read on for other articles about 112-84-5, you can contact me at any time and look forward to more communication. Recommanded Product: Erucamide.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics