Adding a certain compound to certain chemical reactions, such as: 118753-70-1, name is tert-Butyl bis(2-chloroethyl)carbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 118753-70-1, 118753-70-1
To a stirred solution of 2-(4-fluorophenyl)acetonitrile (3.2 g, 23.7 mmol) and ie/ -butyl bis(2-chloroethyl)carbamate (DM, 6.69 g, 23.7 mmol) in DMF (40 mL), NaH (60percent, 2.8 g, 71.1 mmol) was added and the reaction mixture was stirred at 60C for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was quenched using water and extracted with EtOAc. The combined organic layer was washed with brine, dried over anhydrous Na2S04 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using 10percent EtOAc/hexane to afford compound DN (4.2 g, 58percent) as a thick oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl bis(2-chloroethyl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; VPS-3, INC.; YATES, Christopher, M.; (397 pag.)WO2018/165520; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics