Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: https://www.ambeed.com/products/2491-20-5.html, 2491-20-5, Name is H-Ala-OMe.HCl, molecular formula is C4H10ClNO2, belongs to amides-buliding-blocks compound. In a document, author is Wang, Biyun, introduce the new discover.
Silver-promoted C-F bond formation in alpha-bromoamides by using AgF under mild conditions is reported. This simple method enables access to tertiary, secondary, and primary alkyl fluorides involving biomolecular scaffolds. This transformation is applicable to primary and secondary amides and shows broad functional-group tolerance. Kinetics experiments revealed that the reaction rate increased in the order of 3 degrees>2 degrees>1 degrees alpha-carbon atom. In addition, it was found that the acidic amide proton plays an important role in accelerating the reaction. Mechanistic studies suggested generation of an aziridinone intermediate that undergoes subsequent nucleophilic addition to form the C-F bond with stereospecificity (i.e., retention of configuration). The synthesis of sterically hindered alcohols and ethers by using Ag-I is also demonstrated. Examples of reactions of alpha-bromoamides with O nucleophiles are presented.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2491-20-5. Formula: https://www.ambeed.com/products/2491-20-5.html.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics