869494-16-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 869494-16-6, name is tert-Butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate, A new synthetic method of this compound is introduced below.
A suspension of 3,6-diaza-bicyclo[3.1.1]heptane-6-carboxylic acid tert-butyl ester (182 mg, 0.918 mmol), 2-fluoro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyridine (819 mg, 3.67 mmol) and K2C03(S) (634 mg, 4.59 mmol) in DMSO (918 was heated to 90 ¡ãC, then treated with water (5 mL). The resulting mixture was stirred for 1 hour at 90 ¡ãC, then cooled to ambient temperature and filtered to cleanly provide the title compound (1.0 g, 41percent yield). MS (apci) m/z = 320.1 (M+H).
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Reference:
Patent; ANDREWS, Steven W.; BLAKE, James F.; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MORENO, David A.; REN, Li; WALLS, Shane M.; (421 pag.)WO2018/136661; (2018); A1;,
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