Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 811442-84-9, name is tert-Butyl (14-amino-3,6,9,12-tetraoxatetradecyl)carbamate, A new synthetic method of this compound is introduced below., 811442-84-9
TSTU (70 mumol), DIEA (80 mumol) and Boc-NH-PEG4-NH2 (68 mumol) are added to BDP acid 12 (68 mumol) in 1 mL DMF at 0 C. After 10 min, the ice bath is removed and stirring is continued for 2 h at room temperature (RT). The reaction mixture is poured over 3 mL ice cold water and purified by preparative HPLC. After concentration and lyophilization, Boc amine monomer 13 is obtained which is further treated with 1 mL 95% trifluoroacetic acid (TFA), and the solution is stirred at RT for 2.5 h. The excess TFA is removed by N2 stream. After lyophilization, the BDP acid conjugated terminal amine monomer 14 (87%) is obtained without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Bhushan, Kumar Ranjan; Misra, Preeti; US2014/58071; (2014); A1;,
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